Add in small towns and mouth-watering Southern food, and you've got yourself a magical Mississippi vacation on U.S. Highway 49. However, there's a catch to driving one of the state's main highways.

McHENRY., Miss. (WLOX) - Sunday afternoon, a multi-vehicle accident is slowing traffic on Highway 49 in McHenry. According to Mississippi Highway Patrol officials, two vehicles were involved in a ...

Afterward, hit the country roads North on Hwy 49 toward Greenwood. You’ll hit your first landmark in Bentonia, the legendary Blues Front Café, before cruising through Yazzo City on up to Greenwood.

GULFPORT, Miss. (WLOX) - With Friday’s ribbon cutting, Walmart’s “Store of the Future” opened to customers on Hwy 49 in Gulfport. The superstore remodel is the only one in Mississippi, and ...

A stretch of Highway 49 between Richland and Florence has been under construction for years. It’s been the punchline of a few jokes and memes on social media.Mississippi Department of Transportation ...

The 10 best things to do in Mississippi Abuzz with music heritage – it is where the blues was born, after all – and great for nature, food and civil rights history, Mississippi deserves to be ...

Based on a crack revealed during a scheduled inspection today, the Mississippi Department of Transportation will close the bridge located on Country Club Road at Highway 49 immediately.

According to the Mississippi Department of Transportation and the Rankin County Sheriff's Office, all lanes of Highway 49 near Gunter Road had to be shut down Monday evening because of a propane gas ...

In late February, the City of Hattiesburg and its partners will begin a multi-phased traffic improvement project for a stretch of Highway 49 from O’Ferral Street to Adeline Street.

Here are five things we want to see from Mississippi State's football team in its final six games of the season . 247Sports. 247Sports Home; FB Rec. FB Recruiting Home; News Feed; Team Rankings; ...