Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, ...

While effective, this process could result in adverse reactions to the non-human antibodies ... the antivenom cocktail proving effective in mouse models, the team now looks to test its efficacy ...

Cocktails of small molecule drugs and monoclonal antibodies — artificially made copies of powerful human antibodies — against the most important toxin families may be able to neutralize the ...

Background In a subset of patients, anti tumour necrosis factor (TNF) therapeutic antibodies are immunogenic, resulting in the formation of antidrug antibodies (ADAs). Neutralising ADAs compete with ...

Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria. A novel class of antibodies that binds to ...

While mouse monoclonal antibodies are specific, they are extremely immunogenic and can potentially induce human anti-mouse antibody (HAMA) responses, effectively compromising therapeutic ...

The poster presentations will highlight 9 drug assets and 7 gene-edited humanized mouse models ... GARP/TGFB1 mice for testing novel anti-human GARP antibodies Poster number: 18 Date: November ...

Humanized antibodies represent a major type of antibody drug. The clinical application of mouse mAbs is limited by the human anti-mouse antibody (HAMA) response, which not only neutralizes these ...

Multiple antibodies that recognize tau protein were also compared including AT8 anti-tau, HT7 anti-tau ... them first in tissue from a transgenic mouse model, hTau (Andorfer et al., 2003), that ...

No. TNA-Y58) captured on CM5 chip via anti-mouse antibodies surface can bind Human TNF-alpha, His Tag (active trimer) (Cat. No. TNA-H5228) with an affinity constant of 0.323 nM as determined in a ...