Among patients with advanced PIK3CA-mutated, HR-positive/HER2-negative breast cancer, Itovebi-based treatment generated ...

Internalization and degradation of HER2 ... breast cancer Mechanisms of action of trastuzumab include inhibition of HER2 extracellular domain proteolysis, disruption of downstream signaling ...

This ligand-receptor binding in turn induces tyrosine kinase activity within the cytoplasmic domains of these receptors, which leads to activation of downstream signaling pathways, in particular ...

Zenocutuzumab helps fill an important need for patients with advanced pancreatic cancer and NSCLC with NRG1 gene fusions, said Alison Schram M.D., ...

The PI3K signaling pathway is commonly dysregulated ... human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has an abnormal phosphatidylinositol-3-kinase catalytic subunit ...

Cancer has a high mortality rate and is the main factor ... which enhances tumor metastasis by activating the downstream STAT3 signaling pathway. Therefore, the CADM1/HER2/STAT3 axis has broad ...

TGF-β signaling pathway TGF-β transduces signaling through SMAD or ... therapy Cancers with activating BRAF-mutations or EGFR-mutations as well as HER2-positive cancer are often treated with small ...

D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...