This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...

Background: Variable rates of HER2 protein overexpression and gene ... they had measurable lesions (n = 4) or elevated cancer antigen 125 level and non-measurable lesions (n = 3).

Figure 1: Key signaling pathways and targeted factors ... several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and ...

There is therefore increasing evidence to support the concurrent inhibition of two or more receptors along with signal transduction ... mechanism of HER2 upregulation in breast cancer, and the ...

In a nutshell Researchers discovered that omega-6 fatty acids (common in vegetable oils and processed foods) can fuel triple-negative breast cancer growth through a protein called FABP5, while not ...

A new review was published in , Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." ...

Biotechnology company Celcuity’s (CELC) stock is down over 8% since it released its Q4 financial results yesterday, indicating that the company ...

ER+/PR+ breast cancer is a subtype of ER positive breast cancer where the tumor cells express both estrogen receptors (ER) and progesterone receptors (PR) on the surface. As the most common type ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

Researchers are shedding new light on the link between diet and cancer growth—especially the way certain fats may fuel ...

The firm believes VVD-159642 has the potential to treat a broad patient population, including those with RAS- and HER2-overexpressed tumors.