A research led by the IBB-UAB has managed to decypher the structure of the human protease SENP5, implicated in ...

Whether antiretroviral therapy (ART) is always completely suppressive, or HIV might continue to replicate at low levels despite ART in some people with HIV (PWH), is still debated. Here, we ...

Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

The Trump administration's plan to cut funding for HIV vaccine research comes at a time when the field is making substantial ...

A new UVA study finds that HIV drugs like NRTIs may reduce Alzheimer's risk by 10% annually, suggesting potential for repurposing in dementia prevention.

PIs block protease, an enzyme that HIV needs as part of its life cycle. PIs include: atazanavir (available as the stand-alone drug Reyataz or combined with cobicistat in the drug Evotaz) ...

Protease inhibitors aren’t used on their own to treat HIV; they’re used together with other treatments. They are used mainly when patients fail first-line therapies.

Protease inhibitors are drugs used to treat HIV, along with viral infections such as hepatitis C and COVID-19. They block protease, an enzyme HIV and other viruses need to make copies of themselves.

What the 24-week data showed—which dovetails into the 48-week data as well—is that first of all, there was significant efficacy. 2 When these persons with HIV were either maintained on what ...

HIV-1 protease inhibitors are unique among anti-HIV-1 drugs in that they have very high potency and they also have a very high genetic barrier to resistance. The viral protease is essential in the ...