The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations. Nature Structural & Molecular Biology , 2019; DOI: 10.1038/s41594-019-0238-6 Cite This Page : ...

Chemists discover structure of glucagon fibrils Study may be a step toward shelf-stable versions of the hormone, which is used to control diabetes.

Glucagon given to patients now is powdered and has to be dissolved in liquid before injecting. The reason is that the hormone tends to form clumps called amyloid fibrils if it is stored as a liquid.

Recently, scientists at SIMM determined the crystal structure of GCGR in complex with a glucagon analogue and partial agonist NNC1702. This structure reveals, for the first time, the molecular ...

A new study from Imperial has shown that the physical structure of food influences the hormones released as part of digestion. These hormones include glucagon-like peptide-1 (GLP-1), GIP and PYY, as ...

Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, ...

Insulin and glucagon work together to regulate blood sugar levels and ensure that your body has a constant supply of energy. Insulin and glucagon are hormones that help regulate the levels of ...

However, when obese mice without INSP3R1 were chronically treated with glucagon, the hormone had no effect. “These results provide new insights into glucagon biology and suggest that mitochondrial ...

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as ...

Glucagon Receptor Structure Offers New Opportunities for Type 2 Diabetes Drug Discovery. PUBLISHED ON January 04, 2018 10:23 AM - Complex structure of a class B GPCR bound to an analogue of its ...

Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, ...

- Complex structure of a class B GPCR bound to an analogue of its endogenous ligand ignites new excitement in GPCR research SHANGHAI, Jan. 4, 2018 /PRNewswire/ -- Class B G protein-coupled ...