Esophageal adenocarcinoma (EAC), one of two major forms of esophageal cancer, is the sixth most deadly cancer worldwide for which no effective targeted therapy exists.

Abstract. To identify genetic changes related to tumor progression and find out diagnostic and prognostic genetic markers in gastrointestinal stromal tumors (GISTs), 95 tumor samples (24 benign GISTs, ...

Total 497 GIST patients were involved in present study, with a median age of 60 years (range 23–90) and 55.9% was male. Stomach and small bowel were the most common sites of primary disease (59. ...

SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST) ...

Esophageal adenocarcinoma (EAC), one of two major forms of esophageal cancer, is the sixth most deadly cancer worldwide ...

Carney stratakis syndrome – GIST gastrointestinal stromal tumor – surgical pathology criteria. Stanford University School of Medicine. Accessed June 14, 2021. Valencia E, Saif MW. Neurofibromatosis ...

With the tumor-agnostic FDA approvals of pembrolizumab in dMMR and TMB-H solid tumors (≥ 10 mutations per Mb DNA) and of larotrectinib and entrektinib in NTRK fusion–positive solid tumors, multigene ...

Correspondence Published: August 1998 Familial gastrointestinal stromal tumours with germline mutation of the KIT gene Toshirou Nishida, Seiichi Hirota, Masahiko Taniguchi, Koji Hashimoto, Koji ...

June 19, 2025 Testicular sex cord-stromal tumours (TSCSTs) are relatively rare, accounting for ~5% of all testicular neoplasms. They were historically classified into Leydig cell tumour, Sertoli cell ...

Emerging evidence indicates that lactylation modification is closely associated with the initiation and progression of gastrointestinal tumors, including gastric cancer, hepatocellular carcinoma, ...

Professor in Liver Tumour Immunology Interim Director of the Centre for Liver and Gastrointestinal Research We utilise cutting edge laboratory and human systems to delineate key mechanisms, discover ...