Imagine the magnificent glaciers of Greenland, the eternal snow of the Tibetan high mountains, and the permanently ice-cold ...

Chronic inflammation occurs when the immune system is stuck in attack-mode, sending cell after cell to defend and repair the ...

Excessive physical exercise, especially without adequate rest, can damage the human body in various ways. In severe cases, it ...

Chronic inflammation occurs when the immune system is stuck in attack-mode, sending cell after cell to defend and repair the ...

Nine of the ten GAPs for Ras subfamily GTPases contain a C2 domain immediately N-terminal to their GAP domain. Studying the archetypal GAP protein, RasGAP, we find that this C2 domain’s role is to ...

BACKGROUND: Drp1 (dynamin-related protein 1), a large GTPase, mediates the increased mitochondrial fission, which contributes to hyperproliferation of pulmonary artery smooth muscle cells in pulmonary ...

Neurofibromatosis type 1 (NF1) or von Recklinghausen disease is the most common autosomal dominant inherited disorder in humans, affecting approximately 1 in 3,000 individuals. 1 The pathogenesis of ...

Abstract Tightly regulated spatio-temporal Rho GTPase activity patterns regulate morphogenetic processes such as cell migration. Emerging evidence suggests that binding of Guanine nucleotide exchange ...

Protein purity was assessed using standard SDS-PAGE blotting. The protein concentration was quantified and normalized among samples in an elution buffer prior to use in the assays. The GTPase activity ...

Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved ...