Mutant huntingtin abnormally interacts with the mitochondrial fission GTPase dynamin-related protein-1 (DRP1) in mice and humans with Huntington's disease, which, in turn, stimulates its enzymatic ...

The P-loop mutant K82A reduces GTPase activity about 15-fold . Western blot analysis against N. punctiforme whole-cell lysate shows that this protein is produced in vivo ( Fig. 1c ).

Ras proteins are normally tightly regulated by factors that switch off the GTPase activity. ... (NF1) gene codes for a Ras GTPase activating protein that causes neurofibromatosis type 1.

Direct detection of GDP for monitoring GTPase, GAP, and GEF activity; Easy to use, two-step format (no coupling enzymes needed) Far-red fluorescent readouts reduce compound interference; ...

(HealthDay News) — The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery, according to a ...

AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein kinase kinase, MT mutant, Pi inorganic phosphate, P13K phosphoinositide 3-kinase ...

Bristol Myers Squibb Co. has identified new GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer.