News

Nature26d
Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint
As might be expected from its role in G1-S transition, the retinoblastoma protein (RB) is critically important in achieving the required cell cycle withdrawal. RB knock-out mice die between day 13 ...
Zentalis Pharmaceuticals Reports First Quarter 2025 Financial Results and Operational Progress
Detailed price information for Zentalis Pharmaceuticals Inc (ZNTL-Q) from The Globe and Mail including charting and trades.
ascopubs.org25d
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline
A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology ...
ascopubs.org4d
Phase II trial of lenvatinib (LEN) plus pembrolizumab (PEMBRO) for disease progression after PD-1/PD-L1 immune checkpoint inhibitor (ICI) in metastatic clear cell renal cell ...
FRACTION-RCC: Innovative, high-throughput assessment of nivolumab + ipilimumab for treatment-refractory advanced renal cell carcinoma (aRCC). Biomarker analyses from the phase III CheckMate 214 trial ...
Hosted on MSN25d
U.S. border officials reveal what contraband was seized at additional B.C. checkpoints
U.S. Customs and Border Protection is revealing some details about a multi-day border checkpoint operation that caused major northbound delays for travellers heading back into Canada. Multiple ...
The EMBO Journal4d
Altering metabolism programs cell identity via NAD +-dependent deacetylation
Here, we show that forcing a metabolic change in embryonic stem cells (ESCs) promotes a developmental identity that better approximates the inner cell mass (ICM) of the early mammalian blastocyst in ...
C&EN25d
Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, People’s Republic of China Anhui Province Key Laboratory of Functional Compound Seasoning, Anhui Qiangwang ...
Frontiers22d
Single-cell transcriptomics and machine learning unveil ferroptosis features in tumor-associated macrophages: Prognostic model and therapeutic strategies for lung adenocarcinoma
The high-risk group was enriched in tumor progression pathways (like epithelial-mesenchymal transition, cell cycle checkpoints), exhibited low expression of immune checkpoint genes (BTLA, CD47), and ...
Frontiers18d
Prognostic value of the systemic immune-inflammation index in non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
To address this critical gap, we conducted a comprehensive meta-analysis to assess the prognostic value of SII in NSCLC patients treated with immune checkpoint inhibitors ... (5) Animal and cell-based ...
PNAS3d
Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex
Contributed by Dinshaw J. Patel, January 6, 2021 (sent for review December 2, 2020; reviewed by Na Yang and Keqiong Ye) The Shieldin complex, composed of REV7, SHLD1, SHLD2, and SHLD3, protects DNA ...
eLife25d
Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in Drosophila
School of Life Science and Technology, ShanghaiTech University, Shanghai, China Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, ...