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Both of these proteins are found in endothelial cells and renal tubular cells, especially in the proximal tubular cells. Fructose can be phosphorylated via hexokinase, but is displaced by glucose, ...

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This is significant in that the metabolism of fructose is distinct from glucose, as phosphorylation by fructokinase is not rate limited, thus resulting in overwhelming production of saturated FFA.

Figure 1. Location of V62, T65, W99, D158, Y214, V455, and A456 in the open (A) (Protein Data Bank entry 1V4S>) and closed (B) (Protein Data Bank entry 1V4S) conformation.

Fructose is then metabolised by fructokinase in the proximal tubule, which can lead to inflammation and fibrosis of the renal parenchyma as evidenced by Roncal-Jimenez et al., who demonstrated that ...

Objectives To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. Design Cross-sectional. Setting Chinandega and León municipalities, a MeN hotspot on the Nicaraguan ...

The genes involved in these pathways were predominantly annotated as hexokinase, 6-phosphate fructokinase, and alkaline galactosidase. Additionally, pathways involved in amino acid synthesis and ...