Figure 1. Location of V62, T65, W99, D158, Y214, V455, and A456 in the open (A) (Protein Data Bank entry 1V4S>) and closed (B) (Protein Data Bank entry 1V4S) conformation.

The first enzyme to metabolize fructose is fructokinase (also known as ketohexokinase [KHK]). The metabolism of fructose to fructose-1-phosphate by KHK occurs primarily in the liver, ...