Antibody therapeutics’ drug discovery and development stage requires careful assessment of FcγR binding in order to ensure the safety and efficacy of the final therapeutic. This includes wild ...

Our team’s strong focus and execution over the last twelve months lay the groundwork for a potential breakthrough year for iTeos in 2025. As we advance multiple trials evaluating belrestotug + ...

6 These mechanisms include C1q binding leading to complement-dependent cytotoxicity, direct induction of apoptosis, and Fcγ receptor (FcγR)-mediated destruction, which includes antibody-dependent ...

LTZ-301 is a novel myeloid engager bi-specific antibody that depletes CD79b+ B-cells via enhancing Fc-gamma receptor (FcγR)-independent antibody dependent cellular phagocytosis (ADCP). CD79b is a ...

This review summarizes the role of T cells in ITP. Another mechanism involved is Fcγ receptor (FcγR)-mediated phagocytosis, which contributes significantly to platelet destruction (18). In ITP, ...

- Topline interim dataset from GALAXIES Lung-201 with >240 patients anticipated in 2Q25 - Interim datasets from GALAXIES H&N-202 and TIG-006 HNSCC with ~200 patients anticipated in 2025 ...

Real-World Utilization and Performance of Circulating Tumor DNA Monitoring to Predict Recurrence in Solid Tumors BMS-986004, a single, one-time dose of 1,500 mg was identified as the safe and ...

1 Department of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 2 Department of Psychiatry, Yunnan Provincial Hospital of Infectious Diseases, Yunnan ...

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109, United States Biointerfaces ...