The results showed promising anti-tumor efficacy of sunvozertinib in relapsed or refractory non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations ...

There are more than 100 changes that can happen to EGFR. One is an exon 20 insertion. This mutation has few effective treatments. But we're getting to know EGFR changes better, so new treatment ...

exon 20 insertion mutations, as detected by an FDA-approved test. The approval was based on data from the phase 3 PAPILLON trial (ClinicalTrials.gov Identifier: NCT04538664), which included 308 ...

It is caused by homozygous disruption of the survival motor neuron 1 (SMN1) gene by deletion, conversion, or mutation. Although no medical ... a proof of principle for identifying modifiers of SMN2 ...

A new editorial paper titled "Latest updates on MET targeted therapy for EXON 14 mutations in lung cancer" has been published in Oncotarget. In their new editorial, researchers Mira Al Jaberi ...

The SMN2 gene has a nucleotide substitution ... This phenomenon can be explained by the presence of another mutation that introduced a new exon splice enhancer causing higher production of the ...

This ASO corrects mis-splicing of the SMN2 gene ... long ASOs spanning the entire cryptic exon. They tested 250 of them in human neuroblastoma cells that carried two copies of the ALS/FTD-linked N352S ...

New treatments may stall lung cancer progression in patients with EGFR exon 20 insertion mutations. After spending a warm spring day in 2022 pulling weeds and planting perennials, Renata Muller, 66, ...

In this case, the mutations in EnhP disrupt a single "enhancer" instead of a single gene. Our genomes contain hundreds of thousands of DNA elements that are thought to act as enhancers.

Michelle Afkhami, MD, of City of Hope, joins The American Journal of Managed Care® (AJMC®) for a discussion on EGFR exon 20 insertion positive mutations in non-small cell lung cancer. Michelle ...

Treatment pattern and outcomes in patients with uncommon or compound EGFR mutations in India: CRSF 2020-03 study. This is an ASCO Meeting Abstract from the 2022 ASCO Annual Meeting I. This abstract ...

Experts explain the presence and role of EGFR exon 20 insertion mutations in non–small cell lung cancer and highlight the role of molecular profiling. Shared insight on how molecular profiling can ...