Mutations have conventionally been categorized as either those arising in the germline or somatic mutations acquired during life ... cause of a wide variety of human diseases (see Table S1 ...

Figure 1: Detection of somatic mutations acquired in early human embryogenesis ... wide mean WGS coverage + 1.645 × s.d.; for example, the cutoff is approximately 46× in typical 30 ...

Some gene mutations can be either hereditary or acquired. For example, most p53 gene mutations are somatic, or develop during adulthood. Much less commonly, p53 mutations can be inherited ...

As we age, our cells slowly accumulate random mutations in their genes, many of which are harmless. These are known as ...

Source: BMC Biology Somatic ... including humans. They also accumulated linearly over time, with species with a higher rate of mutations having a shorter lifespan. For example, giraffes, which ...

Somatic mutations are slight variants in genes that are acquired in life after birth ... phenomenon with ancestry-specific determinants and human health consequences. The non-coding variant ...

the quantity of somatic mutations acquired over each animal's lifetime was relatively similar. On average a giraffe is 40,000 times bigger than a mouse, and a human lives 30 times longer ...

So long is the human genome ... that make sperm, for example, are constantly dividing to make more sperm, but the mutation rate in sperm is less than one-tenth of that somatic cells.

Researchers have documented that corals can pass mutations acquired ... for example in an egg or sperm cell. Mutations that occur in the rest of the body, in the somatic cells, were thought ...

In a discovery that challenges over a century of evolutionary conventional wisdom, corals have been shown to pass somatic mutations—changes to the DNA sequence that occur in non-reproductive ...