To Shakespeare's Hamlet, we humans are "the paragon of animals." But recent advances in genetics are suggesting that humans ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key ... have a role in disease progression. For example, men with inherited or acquired ...

Somatic mutations are genetic alterations that occur after conception. Unlike germline mutation, somatic mutations are not present in most body cells and develop sporadically, without a known family ...

The researchers acquired ... found one example of protection in the human esophagus. By middle age, many esophagus clones—often making up the bulk of esophagus tissue—have mutations disrupting ...

For example, certain mutations are more common in people who smoke who develop lung cancer, while other mutations are often seen in never-smokers who develop the disease. Somatic gene mutations are ...

The mutation calling software include: sambamba, speedseq, varscan, shimmer, strelka, manta, lofreq_tar. It identifies somatic and germline variants from whole exome sequencing (WXS), RNA sequencing ...

Next, the team is working towards identifying other acquired mutations that might ... the Brain Somatic Mosaicism Network, the Psychiatric Genomics Consortium, the Allen Discovery Center for Human ...

While some patients have inherited variants that you can find in a blood sample, about 90 percent of patients with vascular anomalies have acquired somatic mutations, or mutations that are not ...

Somatic mutations are slight variants in genes that are acquired in life after birth ... phenomenon with ancestry-specific determinants and human health consequences. The non-coding variant ...

Over recent decades, we have witnessed remarkable progress in the field of DNA research, owing to the completion of landmark projects such as the Human ... for example in an egg or sperm cell.

Researchers have documented that corals can pass mutations acquired ... for example in an egg or sperm cell. Mutations that occur in the rest of the body, in the somatic cells, were thought ...