ABSTRACT: This article provides a comprehensive review of various approaches to targeted drug delivery for liver cancer, an area of significant need due to the limited effectiveness of current ...

Bile acids are continuously recycled via the enterohepatic circulation to maintain metabolic balance as the liver's final product of cholesterol metabolism. When bile flow is obstructed ...

20 have shown that in rats with ligated common bile ducts, the rate of cholesterol synthesis may increase. Conversely, when the enterohepatic circulation of bile acids is interrupted by ...

Our data indicate that interruption of the enterohepatic circulation of bile salts results in a relative bile-salt deficiency and a defect in the intraluminal phase of fat absorption. Four ...

[M]aralixibat 570 μg/kg administered twice daily represents a new non-surgical, pharmacological option to interrupt the enterohepatic circulation ... serum bile acid outcomes were observed stratifying ...

Dynamic Regulation: Fine-Tuning Digestive Processes The function of bile acids is not confined to the process of digestion; it extends to dynamic regulation as well. The enterohepatic circulation, a ...

College of Food Science and Engineering, Jilin Agricultural University, Changchun 130033, China Jilin Province Innovation Center for Food Biological Manufacture, Jilin Agricultural University, ...

ASBT, apical sodium dependent bile acid transporter; BSEP, bile salt export pump; FGFR4 ... It is evident that FXR and FGF 15/19 have essential roles in the enterohepatic circulation of bile acids.