How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

In line with that, our review highlights the well-accepted mechanisms of action and resistance to the therapy and discusses the progress that has been made toward successfully overcoming this ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

But sometimes you don’t want that! Sometimes you just want to escape the increasingly insane world out there into an action movie. Netflix has made a few of their own, but the bulk of the best ...

Several therapeutic advances have been achieved over the past two decades for inflammatory bowel disease (IBD). The expanding ...

This article will review the mechanisms of activation of alternative, classical, and lectin pathways, the formation of C3 and C5 convertases, the action of anaphylatoxins, and the ...

All physicians are faced with the challenge of how to help patients with no approved therapies for their diseases. What are ...

A teacher at Drakensburg Secondary School in South Africa is under investigation for allegedly cutting off a Hindu student's religious thread. The South African Hindu Maha Sabha has condemned the ...

There was a lack of published data regarding drug–nutrient interactions for a majority of the drugs commonly administered to patients receiving continuous enteral nutrition. Clinicians should ...

The EMA’s human medicines committee refused marketing approvals for two drugs from Neuraxpharm and Apellis at its January meeting, but both companies have said they will appeal the decision.

Pfizer’s Emblaveo has been approved in the EU with a first-in-class indication in multidrug-resistant (MDR) infections. The drug – a combination of beta-lactam antibiotic aztreonam with beta ...