F230, originally discovered by Eisai Co., Ltd. and exclusively licensed by GNI Group Ltd. to Gyre, is a fully synthetic small molecule designed to selectively block the ETA receptor. By targeting this ...

Background—Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are ...

It is critical to identify potential cancer therapeutic targets. Aberrant activation of the PI3K/AKT/mTOR pathway has a significant role in carcinogenesis. This review summarized oncogenic ...

Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple ...

while pathways pertaining to collagen synthesis and extracellular matrix organization were upregulated. These findings and the altered bioenergetic profile indicative of mitochondrial dysfunction ...

DelveInsight's "FILSPARI Market Size, Forecast, and Market Insight Report" highlights the details around FILSPARI, the first and only ...

The present study demonstrates that chronic blockade of endothelin receptors is associated with an early and sustained increase of ischemia-induced angiogenesis in vivo and that this effect is ...

Roche Colorado Corporation, Boulder Technology Center, 2075 North 55th Street, Boulder, Colorado 80301, U.S.A. Article Views are the COUNTER-compliant sum of full text article downloads since November ...

In an interview last month with former Fox News journalist Megyn Kelly, Makary unveiled plans for a new regulatory pathway for rare disease drugs, allowing for their conditional approval based on a ...

Endothelin (ET) is a recently discovered 21-amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These ...

The long pathway to cell organization and growth Date: May 15, 2025 Source: University of California - San Diego Summary: Sterols are among the most abundant lipids in eukaryotic cells, yet are ...