drug is an antagonist of both endothelin type A (ETA) and angiotensin II subtype 1 (AT1) receptors, which are associated with progression of kidney disease. It's in late-stage development for IgA ...

Figure 1. Established vasomotor pathways targeted by current and emerging therapies in PAH. The 3 major pathways (endothelin-1, nitric oxide, and prostacyclin) involved in the regulation of pulmonary ...

endothelin-1; IL-6, interleukin 6; and TGF-β, transforming growth factor-β. Taken together, cardiac remodeling is a sophisticated pathophysiological process in HF and involves many types of cells, ...

Locally produced vasodilator substances may counteract the constrictive effects of endothelin-1. [31] NO, which is also produced by stellate cells, is a well-characterized endogenous antagonist to ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Consecration and 10 steps to cleansing. They do dovetail with our responsibilities. What is required of a priest and how does the priesthood parallel with those who are Christians? Can you draw a ...

Notably, both loss-of-function and gain-of-function approaches identified the critical roles of miR-34a in cardiovascular apoptosis, autophagy, inflammation, senescence and remodeling by modulating ...

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Systemic vascular abnormalities were recently highlighted in patients with INOCA potentially supporting a therapeutic role for targeted vascular therapy, for example, using selective endothelin-A ...