A selection of patient focused media related to the OPC1 program is available on the Media page of the Lineage website. The Delivery of Oligodendrocyte Progenitor Cells for Spinal Cord Injury: ...

“Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing.” SCI remains one of the most devastating medical ...

During development, neural stem cells in the spinal cord differentiate into various neural cells that form complex circuits. As the spinal cord matures, these progenitor cells lose their ...

At E12.5, the MCA trunk and main branches are lumenized and show mural cell progenitor recruitment ... and nearby arterial endothelial cells and not through recruitment of microvascular cells. To ...

A major bottleneck in the identification of these cell types during hiPSC differentiation is the lack of lineage tracing tools that have been extensively used in murine models to understand the ...

A Cre-loxP-mediated genetic lineage-tracing system was used to track epicardial fate differentiation. Epicardial-derived progenitor cells (EDPCs ... the epicardium can also generate endothelial cells, ...

Endothelial cells appear to emerge from diverse progenitors. However, to which extent their developmental origin contributes to define their cellular and molecular characteristics remains largely ...

Genetic lineage tracing based on Csf1r-Mer-iCre-Mer showed no contribution of EMPs to brain endothelial cells identified by several markers. We also generated a knock-in mouse line by inserting an ...

Introduction: Stem cell therapy represents great promises to myocardium regeneration. Multipotent c-Kit pos cardiac progenitor cells (CPCs) are able to differentiate into endothelial cells ...

Lineage-tracing approaches are essential to obtain information on the long-term self-renewal potential and fate choice of stem and progenitor cell populations. Population-based methods involving ...

Cardiovascular risk factors contribute to atherogenesis by inducing endothelial-cell injury and dysfunction. We hypothesized that endothelial progenitor ... endothelial-cell lineage was performed ...