ATACs work by binding to and shuttling disease-causing proteins from circulation to the hepatocyte endolysosome, where the unwanted proteins are degraded. The presentation will highlight initial ...

Other TLRs—TLR 3, TLR7, (TLR 8 in humans, but not mice), and TLR 9—reside inside immune cells, in a compartment known as the endolysosome, where bits of foreign substances usually end up.

As a complementary approach, MTACs harness the M6P receptor and work by degrading pathogenic proteins in the endolysosome of M6PR-expressing cells, which include hepatocytes but also encompass ...

In its late phase, the endosome merges with lysosomes that contain enzymes, forming an endolysosome. Within this structure, the enzymes break down both material from the body and foreign material.

This stunts calcium flow from the ER to lysosomes, stalling the cellular waste disposal system. Knocking out APP normalizes endolysosome function. Scientists praised the research. “This is beautiful ...