began by screening a large library of compounds for activators of wild-type POLγ, using a high-throughput in vitro DNA synthesis ... Cryogenic electron microscopy revealed PZL-A binds to a ...

Cryoelectron microscopy is a method for imaging frozen ... POLG mutations impair mitochondrial DNA replication and cause diverse mitochondrial diseases. Here, the authors show that structural ...

Mitochondria — the powerhouses of cells — carry unique DNA that is mutated in specific diseases ... The team used a technique ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have ...

Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth – a key process in the origin of life.

Today we are machining some metal inside the scanning electron microscope! By creating a custom fixture, we can manually advance a carbide cutter and cut metal inside the vacuum chamber of my SEM.

The orbital angular momentum of electrons has long been considered a minor physical phenomenon, suppressed in most crystals and largely overlooked. Scientists have now discovered that in certain ...

This study finds these bacteria as the first example of an organism using ADP-ribose modification of DNA as a mechanism for regulating gene transcription and cellular replication. The ...

This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data ...

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