Adding ICIs to chemotherapy ± antiangiogenic therapy improves survival outcomes in advanced NSCLC that is resistant to EGFR-TKIs.

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Radiation therapy can promote the epidermal growth factor receptor (EGFR) ligand amphiregulin, which increases growth of ...

Breast cancer is the most commonly diagnosed cancer among women worldwide and represents a major public health concern due to ...

A new nanozyme-antibody platform selectively targets HER2-positive tumors, disrupting gene expression and reducing metastasis ...

A new treatment option, Datroway (datopotamab deruxtecan or Dato-DXd), is now available for people with non-small cell lung ...

In a recent study, researchers have uncovered the biological trigger behind the dangerous immune-related adverse events (irAEs) that occur when the epidermal growth factor receptor (EGFR ...

During a live event, Alexander I. Spira, MD, PhD, and participants NGS testing practices and the rationale behind their approaches.

We previously established that the barrier defect can be rescued by re-establishing active ERK signaling independent of EGFR through transgenic over-expression of SOS under the K5 promoter (EGFR Δep ...

For overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) gene expression was analyzed with Kaplan-Meier and Cox-proportional hazard models. Significant gene expression ...

Pharmacological inhibition of EGFR markedly decreased the rupture rate of intracranial aneurysms without altering the formation rate. EGFR inhibition also significantly reduced the mRNA (messenger RNA ...

Tgfβ signaling collaborated with a parallel Egfr-Mek1/2-Erk1/2-Fra1 pathway to coordinate the expression of a subset of pro-motility genes, including Axl. Interestingly, the integration was also ...