These data build upon the body of clinical evidence which supported the recent U.S. Food and Drug Administration (FDA) approval of AMVUTTRA ® (vutrisiran) for the treatment of the cardiomyopathy of ...

[29] Clinical feature in adults Transient depression of myocardial contractility; myocardial necrosis (cTnT elevation); arrhythmia Dilated cardiomyopathy ... DOX: Doxorubicin; Fe 2+: Iron ...

The most common toxin is an anti-cancer drug called doxorubicin. In most cases, dilated cardiomyopathy in dogs is genetic and usually happens to certain breeds. The disease happens slowly ...

Despite recent progress in cancer therapeutics, doxorubicin and other anthracyclines remain cornerstones of pediatric cancer treatment. However, they come with a risk of late-onset cardiomyopathy ...

High doses of doxorubicin put cancer patients at risk for developing dilated cardiomyopathy. Previously, we showed that doxorubicin treatment decreases SIRT3 (sirtuin 3), the main mitochondrial ...

Background: Doxorubicin is a widely used and effective chemotherapy, but the major limiting side effect is cardiomyopathy which in some patients leads to congestive heart failure. Genetic variants in ...

Anthracycline cardiomyopathy was the first serious cardiovascular complication to draw the attention of oncologists and cardiologists around the world. Anthracycline drugs such as doxorubicin, ...

Anthracycline-based chemotherapy can result in the development of a cumulative and progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed anthracyclines in the ...

A lawsuit was filed against Dr T. In the lawsuit, Mrs B claimed that the doxorubicin-induced cardiotoxicity had caused her to suffer permanent cardiomyopathy, severe mitral valve regurgitation ...