Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Am J Health Syst Pharm. 2008;65(24):2347-2357. Administer medications via the oral route when possible. Determine the enteral feeding tube size (e.g., small bore or large bore), insertion site (e ...

Examples of osmotic laxatives include milk of magnesia (which also softens stools), sodium phosphates and magnesium citrate.8 Although very effective, they should be used with caution in older ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.5c02751. Discussion of chemicals, synthesis details, characterizations ...

Department of Statistics, University of Oxford, St Giles, Oxford OX1 3LB, U.K.