We characterized the molecular changes induced by docetaxel in two well-known human breast carcinoma cell lines. Two mechanisms of action according to drug concentration were suggested by a ...

Paclitaxel was isolated from the Pacific yew (Taxus brevifolia), and docetaxel, a semi-synthetic taxane analog, from the European yew (Taxus baccata). While each has a similar mechanism of action ...

Docetaxel was administered every 3 weeks ... with two anti-HER2 monoclonal antibodies that have complementary mechanisms of action results in a more comprehensive blockade of HER2 and highlights ...

Study: Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line ... agents targeting HER-2 through differing mechanisms of action has proven more effective than using ...

Further, weekly paclitaxel extended DFS and OS in women with triple-negative breast cancer, whereas docetaxel administered every 3 weeks improved DFS in women with ER-positive, HER-2–negative ...

Plinabulin’s unique, immune-enhancing mechanism of action has a proven anti-cancer benefit that we believe will synergize with docetaxel and Keytruda and re-sensitize patients who progressed after ...

The differences in mode of action and mechanisms of resistance for platinating ... the platinating agent carboplatin, (2) the taxane docetaxel, or (3) a combination of carboplatin and docetaxel.

This review considers trastuzumab's mechanism of action and its clinical value ... received doxorubicin and cyclophosphamide followed by docetaxel alone. The second group received doxorubicin ...

Most physicians and investigators believe that taxane chemotherapy (paclitaxel, docetaxel and cabazitaxel ... our new understanding of the precise action of taxanes in a cancer cell may help ...

Evidence for a Clinically Relevant Mechanism of Action for the Prevention of Chemotherapy-Induced-Neutropenia.” Non-small cell lung cancer (NSCLC) patients received docetaxel chemotherapy plus ...

Dec. 4, 2003 (San Antonio) — Docetaxel (Taxotere) produced better overall survival and longer time to progression than paclitaxel (Taxol) in a randomized head-to-head trial of the two taxanes ...