A nasal spray version of esketamine was more effective for depression that is resistant to treatment than a more commonly used drug, research published Wednesday in The New England Journal of ...

17 In patients with treatment-resistant depression, reductions in depressive symptoms and in the risk of relapse were observed with esketamine nasal spray as compared with placebo nasal spray when ...

While its effectiveness is still being researched, clinical therapists across the country and here at Bryan Medical say it’s ...

More information: Antonio Del Casale et al, Esketamine Combined With SSRI or SNRI for Treatment-Resistant Depression, JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0200 ...

On Tuesday, the government agency announced Spravato nasal spray, also known as esketamine, can now be used "for the treatment of depression in adults who have tried other antidepressant ...

Opens in a new tab or window Esketamine nasal spray (Spravato) monotherapy was helpful in improving symptoms of treatment-resistant depression, a randomized, double-blind trial found. Among 379 ...

"Unlike existing drugs for depression, esketamine does not directly involve serotonin, norepinephrine, or dopamine reuptake," says Dr. Sheline. But it's not entirely known why Spravato works in ...

Spravato (esketamine) is a prescription drug that’s approved to treat certain forms of depression. Esketamine comes as a nasal spray that you inhale. Specifically, Spravato is approved by the ...

Esketamine nasal spray (Spravato) may be used along with an oral antidepressant for the treatment of depression in adults who’ve tried other antidepressant medicines but haven’t benefited from ...

They’ve studied and administered it in controlled, clinical settings to help with treatment-resistant depression and other conditions. Esketamine may be an option for people with major ...

Esketamine targets the glutamate neurotransmitter pathway, offering a novel mechanism for treatment-resistant depression. The treatment is available through a Risk Evaluation and Mitigation ...

Depression masquerading as anger may seem ... A number of treatment approaches for TRD are available, including: Esketamine (Spravato) A nasal spray, Spravato won FDA approval on March 5, 2019 ...