Molecular Assemblies has rethought DNA synthesis from the ground up to develop the Fully Enzymatic Synthesis (FES) process. The company partnered with Codexis to take wild-type terminal ...

DNA Script CEO Thomas Ybert, whose company received an investment from the chemical DNA maker Agilent Technologies in 2020, says it’s only a matter of time before enzymatic synthesis wins out.

DNA enzymatic synthesis represents an enormously valuable next step in harnessing the power of DNA replication and our ability to use it for developing cutting-edge, biotechnology solutions.

However, DNA synthesis technologies have been slow to catch up. 1 Michael Daniels, PhD The predominant existing chemical method, phosphoramidite synthesis, was first established in the 1980s.

DNA synthesis is vital to several processes in biopharmaceutical innovation, including the development of gene therapies, CRISPR gene editing, antisense oligonucleotides and RNA therapies.

In contrast, enzymatic DNA synthesis harnesses the power of biological enzymes to do what they do best: synthesize DNA efficiently and accurately without needing or creating any hazardous materials.

Hoose A, et al. DNA synthesis technologies to close the gene writing gap. Nat Rev Chem. 2023;7(3):144-161. Beaucage SL, Caruthers MH. Deoxynucleoside phosphoramidites—A new class of key intermediates ...

Over the last several decades, DNA – the genetic material of life as we know it – has completed a remarkable scientific cycle. In 1953, it was a mysterious blur on an X-ray diffractogram. By ...

The concept was simple, but, Leproust says, “the engineering was hard.” When you synthesize DNA, she explains, the yield, or success rate, goes down with every base added.

New DNA synthesis technique promises rapid, high-fidelity DNA printing Using a natural human enzyme that works in water, process uses no toxic chemicals Peer-Reviewed Publication ...