Sequence gaps were closed by editing the end sequences and/or primer walking on plasmid clones. Physical gaps were closed by direct sequencing of genomic DNA ... of the alignment that were ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome ...

The FDA has endorsed plans for a Phase 2b clinical trial that will test CS1, Cereno Scientific's experimental treatment for PAH.

Two views of an expanded skin cell nucleus from a person with progeria: On the left, antibody fluorescence imaging shows the ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological ...

Huntington's disease is a genetic disorder that kills nerve cells in the brain, causing people to lose their cognitive and ...

Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...

The African wild dog is one of Africa’s most endangered predators. African wild dogs are highly elusive, avoiding human contact and utilising vast, remote territories to remain out of sight.

Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of ...