A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and ... RAD52 is important in protecting stalled DNA replication forks.

Double ring structure protects DNA . Spies and Pichierri had previously discovered that RAD52 is important in protecting stalled DNA replication forks.

Synopsis image By reconstituting eukaryotic DNA replication in vitro, this study addresses the effects of physiological quadruplex secondary structures ... Baretic D, Jenkyn‐Bedford M, Aria V, Cannone ...

Each time a part of a chromosome unwinds for replication, regions of DNA unzip forming a structure that looks like a fork in the road. For replication to proceed, the fork must move down the strand of ...

Superposition of the CMG–fork DNA structure with the CMG–ssDNA structure shows very little change in conformation (SI Appendix, Figs ... MR Botchan, Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a ...

The nephew of a man killed in New York City 15 years ago has been arrested for his murder after officials obtained DNA evidence on a plastic fork connecting him to the slaying.. A grand jury ...

DNA replication. replication fork DNA replication. biological process of producing two identical replicas from one original molecule. replication fork. Vector diagram shows how both strands of the DNA ...

DNA replication. biological process of producing two identical replicas from one original molecule. replication fork. Vector diagram shows how both strands of the DNA helix are unzipped and copied.

Finally, we resolve the DNA-bound structure of the N-terminal BRCT domain in the context of RFC:PCNA:DNA complexes and demonstrate that this domain promotes PCNA loading at replication forks in vitro.