Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in ...

findings often require replication in large cohorts to ensure relevance and validity. To address this, integration and cross-validation of findings across varied cohort studies is vital. We quantified ...

RAPID CITY, SD — In 1994, Tina Marcotte disappeared, and police suspected foul play. About five days later the main suspect was found dead, his head crushed under a forklift at work. What became known ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

A University of Iowa-led study uncovered a unique double-ring structure of the DNA repair protein RAD52 that plays a critical role in protecting stalled DNA replication in cancer cells with repair ...

University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. A University of Iowa-led study ...

Polynucleotide kinase phosphatase (PNKP) has enzymatic activities as 3′-phosphatase and 5′-kinase of DNA ends to promote DNA ligation and repair. Here, we show that cyclin-dependent kinases (CDKs) ...

Large eukaryotic genomes are packaged into the restricted area of the nucleus to protect the genetic code and provide a dedicated environment to read, copy and repair DNA. The physical organisation of ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

Recent findings reveal that early mouse embryos replicate their DNA in a unique, uniform manner, which changes after the embryo grows beyond four cells. This early-stage replication is slower and more ...