Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed ...

Researchers from the University of Iowa have unveiled the structure of a protein that plays a key role in protecting DNA during replication. This discovery may lead to the development of drugs ...

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

Combined genetic and biophysical characterisation establishes that structure stability and probability of structure formation are key determinants of replisome arrest. Mechanistically, replication ...

CMG is known to bind many other proteins, including a leading and lagging polymerase and primase. Thus, the threading of DNA through the CMG helicase at a replication fork determines the orientation ...

The nephew of a man killed in New York City 15 years ago has been arrested for his murder after officials obtained DNA evidence on a plastic fork connecting him to the slaying. A grand jury ...

DNA replication. biological process of producing two identical replicas from one original molecule. replication fork. Vector diagram shows how both strands of the DNA helix are unzipped and copied.

DNA replication. biological process of producing two identical replicas from one original molecule. replication fork. Vector diagram shows how both strands of the DNA helix are unzipped and copied.

Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork ...

Current models propose that a structure-specific nuclease incision is needed to unhook the ICL from the replication fork, followed by the activity of a low-fidelity TLS polymerase enabling replication ...