An evolutionarily conserved small domain in the upper stem of vertebrate Y RNAs has an essential function for the initiation of chromosomal DNA replication. Here we provide a structure–function ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic instability and cancer. Researchers at UNIST and IBS have experimentally ...

secondary DNA structures or any other obstruction to the progression of the DNA replication fork, and is thought to contribute substantially to the oncogenic process. To counteract this threat, the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Topoisomerase II (TOP2) unlinks chromosomes ...

The presence of multiple clusters of runs of asymmetric adenine or thymine is a feature commonly found in eukaryotic replication origins. Here we report that the helicase and ATPase activities of the ...

Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...

DNA replication stress, also referred to as DNA replicative stress, is defined as the slowing or stalling of replication fork progression during DNA synthesis as a result of different insults.

the 'wings' and N-termini of RTP do not form intimate contacts with the DNA. This structure provides insight into the molecular basis of polar replication fork arrest based on a model of ...