Polyploidy, or whole-genome duplication (WGD), is a major mechanism of genome evolution across the tree of life and is ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

Absorption of UV-radiation in nucleotides initiates a number of photophysical and photochemical processes, which may finally cause DNA damage. One major decay channel of photoexcited DNA leads to ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations ...

An updated inventory of about 150 human DNA repair genes was recently compiled by Wood et al., and excellent reviews have also appeared in recent times regarding our current knowledge of the DNA ...

New research from USC Dornsife scientists reveals how cells fix dangerous DNA damage in hard-to-repair areas of the genome — a process that, when it goes wrong, can lead to cancer and other life ...

Manipulating DNA repair proteins can significantly influence base editing efficiency and outcomes. Inhibiting uracil N-glycosylase (UNG) and DNA ligase 3 (Lig3) ...

Randomized trial of standard chemotherapy alone or combined with atezolizumab as adjuvant therapy for patients with stage III deficient DNA mismatch repair (dMMR) colon cancer (Alliance A021502; ...

Nucleic acid amplification is a pivotal technology for gene investigation in molecular biology as well as an indispensable tool for nucleic acid-based analyses across various disciplines. However, the ...

To explore their role, the team disabled these two repair systems in tobacco plants. The plants still grew, though some developed slowly. But under the surface, big changes were unfolding. Without ...