A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer. But ...

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

Cells are then allowed time to recuperate before their DNA is extracted and resolved by PFGE. When cells are allowed time for repair, the original band pattern, instead of the smear associated ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer.

They found that the most common pattern was for the activity to be the same at all three observational points, whether the enzymatic period was during exonuclease repair or DNA extension. “This ...

In its structure, DNA contains a pattern for producing amino acids ... Because almost everything that makes or uses DNA also makes DNA repair proteins, it's possible to rewind the evolutionary ...

A Canadian study suggests that melatonin, a sleep-regulating hormone, may help repair DNA damage caused by poor sleep, ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...