Figure 1: Structure of topo II bound to DNA and AMPPNP. To define the global architecture of a type IIA topoisomerase holoenzyme, we determined what is, to our knowledge, the first crystal ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published ...

In our structure, this region of the DNA has higher B-factors and less well ... were incubated for 30 min at 25 °C. No nucleotide was added to the mixture. Reaction mixtures were filtered through ...

Why is DNA so important? Put simply, DNA contains the instructions necessary for life. The code within our DNA provides directions on how to make proteins that are vital for our growth ...

Thus, synthesis (addition of new nucleotide units ... Vital to this point is the fact that the nature of the tertiary structure of DNA inside cells and viruses is almost completely unknown.

Shown here is the structure of naked DNA -- DNA without all of the proteins ... Each sugar-phosphate-base combination is called a nucleotide. A nucleotide is made up of 30 atoms, plus or minus ...

"This is another mechanism for regulation of gene expression and nuclear structure ... of a new nucleotide may make biologists rethink their approaches to investigating DNA methylation.

DNA is a complex molecule that consists of two strands coiled around each other to form a double helix structure. Comparison of a single ... DNA mutations are changes in the nucleotide sequence of the ...