7b00732. Scoring summary of in-cell PKA activation determined using the FRET biosensor and stimulated with permeable cyclic nucleotide analogs, kinase activity of PKA type Iα holoenzymes without and ...

To address the problematic optimization issue, we propose new joint optimization objectives and a novel Cyclic Differentiable ARchiTecture Search framework, dubbed CDARTS. Considering the structure ...

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that ...

Patients with vitiligo experience impacts on quality of life, emerging therapies offer promising prospects for more targeted ...

In addition, extracellular ATP/adenosine signaling plays a pivotal role in the pathogenesis of neurological diseases. Virtually every cell type in the brain contributes to the elevation of ...

Researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused ...

Find more information on the Altmetric Attention Score and how the score is calculated. Extracellular adenosine plays a key role in promoting bone tissue formation. Local delivery of adenosine could ...

The novel PDE10A inhibitor CPL'36 offers a new mechanism of action and is both safe and effective for acute exacerbations of schizophrenia, new research suggests.

Inobrodib is being developed as a first-in-class oral cancer drug that the company says will be able to treat not only multiple myeloma, but other specific cancers as well.

Adenosine serves as an endogenous modulator of inflammatory and immune processes. Its release can be triggered from almost all cell types by ischaemia, hypoxia, inflammation and oxidative ...