Kinase inhibitors are high-priority drug candidates for a variety of therapeutic applications. Accordingly, there has been a rapid growth in the number of kinase inhibitors and volumes of associated ...

Abstract Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila, including functions in the CNS, however the molecular details are poorly understood. To gain mechanistic ...

For instance, treatment with Senexin B, a highly specific CDK8/19 inhibitor, predominantly downregulated gene expression after 3–5 h; however, between 24 h and 15 days, gene expression was primarily ...

Keywords: immune-related adverse events (IRAE), myositis, immune checkpoint inhibitors, creatine kinase, melanoma, case report Citation: Begaj K, Wilhelm R, Lepper A, Kaufhold M, Veeser J, Grabbe S ...

Washington (7News) — You’ve likely seen the creatine craze on social media, including claims that creatine could be an effective tool for supporting brain health and function in Alzheimer’s ...

Background—Previous studies in humans have indicated that there is less ischemic dysfunction during PTCA when ischemic preconditioning is elicited. However, the clinical relevance of these observatio ...