The role of APC in hyperoxic acute lung injury was tested by studying the physiology of lung injury development, measurement of key coagulation proteins and ... complexes and plasminogen activator ...

∥ Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, United States ⊥ Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, United States ...

Additionally, we present a complete, descriptive ... Due to their dual activity, the contact-kinin pathway not only triggers thrombus formation by activating intrinsic coagulation via FXI (factor XI) ...

15 16 The assessment of individual haemostatic factors and/or inhibitors demonstrates only partly the complex haemostatic process. In contrast, the overall haemostatic potential (OHP) assay is a more ...

Therefore, we sought to investigate the relationship between the activation of coagulation and subsequent systemic inflammatory changes in AMI. Methods and Results— Factor Xa (FXa) bound to tissue ...

Among the many physiological changes that occurred during the transition from an aquatic to a terrestrial lifestyle by early vertebrates, blood coagulation ... to draw a more complete scenario for the ...

Background Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of ...

China Objective Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma ...

Besides, they used the combination of an MK2-specific inhibitor, MK2-IN-3, with the microtubule depolymerizer vinblastine to simultaneously disrupt both the MK2 signaling pathway and microtubule ...

Briefly, cells were treated with 2 μΜ CMPD1 for 4 hours, followed by a wash with complete media and live-cell ... its tumor-specific cytotoxicity likely via two pathways. First, CMPD1 acts as a kinase ...

Following progression to castration-resistant prostate cancer, androgen receptor pathway inhibitors are commonly used. Despite its usage, the precise mechanisms underlying androgen receptor ...