Additionally, we present a complete, descriptive ... Due to their dual activity, the contact-kinin pathway not only triggers thrombus formation by activating intrinsic coagulation via FXI (factor XI) ...

In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...

A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology ...

Following progression to castration-resistant prostate cancer, androgen receptor pathway inhibitors are commonly used. Despite its usage, the precise mechanisms underlying androgen receptor ...

Therefore, we sought to investigate the relationship between the activation of coagulation and subsequent systemic inflammatory changes in AMI. Methods and Results— Factor Xa (FXa) bound to tissue ...

In light of these concepts, current massive transfusion protocols incorporate hemostasis-directed resuscitation, or the pre-emptive administration of blood coagulation products along with packed ...

Among the many physiological changes that occurred during the transition from an aquatic to a terrestrial lifestyle by early vertebrates, blood coagulation ... to draw a more complete scenario for the ...

"We look forward to discussing the data with regulators so we can bring this first-in-class alternative complement pathway inhibitor as the first oral monotherapy to people living with PNH," he added.

Besides, they used the combination of an MK2-specific inhibitor, MK2-IN-3, with the microtubule depolymerizer vinblastine to simultaneously disrupt both the MK2 signaling pathway and microtubule ...