Experiments showed that the coiled-coil domain, whose predicted model extends from one of the periplasmic subdomains toward the outer membrane like a long antenna, was essential in both MmpL4 and ...

Here, we show that a NEver in mitosis Kinase NEKL-3 directly phosphorylates a flexible elbow region between two coiled-coil domains connecting the motor head and tail of an intraflagellar transport ...

Here, we show that a NEver in mitosis Kinase NEKL-3 directly phosphorylates a flexible elbow region between two coiled coil domains connecting the motor head and tail of an intraflagellar transport ...

Thus, the oligomerization of head domains forms the cartwheel ring, and the coiled-coil domain and the unstructured C-terminal region account for the spoke appearance. Cryo-electron microscopy ...

Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in 9 sarcomeric protein genes. The most commonly affected is β-myosin heavy chain (MYH7), where missense mutations cluster in the head ...

Coiled-coil domain-containing protein 80 (CCDC80) plays an essential role in regulating vascular remodeling. In the present study, we aimed to define the role of CCDC80 in the formation and ...

These structures revealed large-scale conformational changes upon activation that appear to be centered on rearrangements within the coiled-coil (CC) domains in the enzyme. Here, a structure-guided ...

Study: Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein. Image Credit: PHOTOCREO Michal Bednarek/Shutterstock Traditional approaches to drug discovery have failed to ...

Activating MET kinase domain mutations define a novel molecular subtype of non–small cell lung cancer that is clinically targetable with the MET inhibitor elzovantinib (TPX-0022).. If you have the ...

We performed systematic directed mutagenesis on the coiled-coil 2 domain of Atg11 in order to map which residues were required for its structure and function. Using yeast-2-hybrid and ...

Mutations in the epidermal growth factor receptor (EGFR) extracellular domain (ECD) are implicated in the development of glioblastoma multiforme (GBM), a highly aggressive form of brain cancer.1–4 Of ...

Disrupting this interaction by point mutations in the FHA or CC2 domains leads to a dramatic accumulation of KIF1A in the periphery of living cultured neurons and an enhancement of the microtubule (MT ...