Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA ...

The magnified region depicts the ROCK2-interacting domain, including both inhibitory phosphorylation sites, and a predicted coiled coil region. When overexpressed in VSMCs, ROCK1 and -2 were localized ...