Meeting the demand for clinically relevant neurodegenerative treatments requires a paradigm shift in how central nervous system (CNS) clinical trials have been designed and executed. Four years ...

Although comprehensive genomic profiling (CGP) expands access to clinical trials, insufficient information-sharing continues to limit access to appropriate trials – particularly in rare cancers ...

We conducted an open-label, phase 2 trial of selumetinib to determine the objective response rate among patients with plexiform neurofibromas and to assess clinical benefit. Children with ...

In patients with stable angina, two strategies are often used to guide revascularization: one involves myocardial-perfusion cardiovascular magnetic resonance imaging (MRI), and the other involves ...

A first-in-human phase 1, multicenter, open-label study of CB-011, a next-generation CRISPR-genome edited allogeneic anti-BCMA immune-cloaked CAR-T cell therapy, in patients with relapsed/refractory ...

For more audio journalism and storytelling, download New York Times Audio, a new iOS app available for news subscribers. transcript This transcript was created using speech recognition software ...

NRG GI008: Colon adjuvant chemotherapy based on evaluation of residual disease (CIRCULATE-US). This is an ASCO Meeting Abstract from the 2023 ASCO Gastrointestinal Cancers Symposium. This abstract ...

Candidates for entry into clinical trials can then be selected based on their effectiveness and safety in disease models. All drugs require data from various toxicological preclinical studies to ...