Enantiomers, or molecule pairs that are mirror images of each other, make up more than half of FDA-approved drugs in use ...

Thus, developing a chemical synthesis reaction that selectively produces one enantiomer of chiral molecules useful in medicine is of great significance in the synthesis of drugs and their precursors.

The importance of chirality -- or 'handedness' -- in drug development was brought to light in a devastating way almost half a century ago with the development of the Thalidomide drug. Prescribed ...

Chiral molecules are those whose structural complexity allows them to have mirror-image, "left-handed" and "right-handed" forms. For drug molecules, usually only one of those forms works - the ...

Scientists at The Scripps Research Institute (TSRI) say they have invented a new technique for constructing chiral drug molecules, whose structural complexity allows them to have mirror-image ...

Chirality is a critical factor in the discovery of drugs derived from natural products. Natural products are intricate organic molecules biosynthesized by living organisms, exhibiting a broad spectrum ...

Hold out your hands, palms up, and move them so they are on top of each other. With a little experimentation—and perhaps a ...

Chiral switches are chiral drugs that have already been claimed, approved and marketed as racemates or as mixtures of stereoisomers, but have since been redeveloped as single enantiomers.

One prominent example of a chiral switch occurred in 2001, when the US Food and Drug Administration (FDA) approved AstraZeneca’s esomeprazole (Nexium), a proton pump inhibitor (PPI) used to ...

The business strategies of companies involved in chiral drug development were cast into doubt in October after Eli Lilly (Indianapolis, IL) decided not to pursue the development of R-fluoxetine ...

Researchers have been actively looking for novel antitubercular medications with little side effects that are effective against drug-resistant strains to solve this problem. The usage of chiral drugs ...

The study was recently published in Advanced Materials. Nearly 56% of all modern drugs and medicine are chiral in nature, and about 90% of those are a mixture containing equal amounts of two ...