Heat shock proteins (HSPs) are central regulators of protein homeostasis as they fold newly synthesized proteins and refold damaged proteins. Heterozygous loss-of- function mutations in the DNAJC7 ...

Because of the broad nature of chaperone action, S1R agonists and antagonists represent potential drug discovery goals for the pharmacotherapeutic treatment of a variety of disorders that result from ...

JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.8, August 27, 2024 ABSTRACT: Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique ...

Maintaining protein homeostasis, or proteostasis, is critical for cell function and survival, so the aberrant aggregations seen in AD indicate an imbalance in proteostasis.

Once the heat shock subsides, these condensates get dispersed with the help of molecular chaperone proteins, facilitating integration of the orphaned proteins into functional mature ribosomes that can ...

Background: Cardiac hypertrophy is one of the heart's adaptive responses, which may play a compensatory role in enhancing cardiac function during stress conditions. However, prolonged hypertrophy ...

ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator. PNAS. Published online July 24, 2023. doi:10.1073/pnas.2303448120 ...

As a major ER chaperone GRP78 plays a key role in folding and processing membrane-bound or secretory proteins, and previous studies by Lee’s team had also shown that when cells are under stress ...

Scientists have discovered a family of metallochaperones (ZNG1) that transfer zinc onto proteins and play a significant role maintaining zinc homeostasis and cellular integrity [Weiss et al, Cell ...

Study identifies first cellular “chaperone” for zinc Findings shed light on worldwide public health problem of zinc deficiency Peer-Reviewed Publication Vanderbilt University Medical Center ...

Protein aggregation is a continuous cellular process and may be a result of misfolding caused by various stressors. Chaperone complexes, in conjunction with interacting ubiquitin E3 ligases, channel ...

FIGURE 1. Canonical and non-canonical functions of prefoldin. Nascent chains that emerge from actively translating ribosomes are subjected to protein folding that is mediated by the protein chaperones ...