The chaperone protein network is your cell's natural defense to maintain homeostasis throughout life, and this study emphasizes the importance of protecting that balance in the aging brain.

Maintaining protein homeostasis, or proteostasis, is critical for cell function and survival, so the aberrant aggregations seen in AD indicate an imbalance in proteostasis.

TAMPA, Fla (April 20, 2021) — Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain – an early step in the development of Alzheimer ...

Understanding how molecular chaperones assist other proteins has great biological and medical importance. Hsp70 is one of the main chaperone classes that play an essential role in protein folding and ...

Many neurodegenerative disorders are characterized by conformational changes in proteins that result in misfolding, aggregation and intra- or extra-neuronal accumulation of amyloid fibrils.

Proteostasis or protein homeostasis is a cellular network essential for the strict control of protein synthesis, ... Cell Stress Chaperones. 2018 May; doi: 10.1007/s12192-018-0897-y.

When excessive misfolded protein accumulates to form protein aggregates, a fraction of the TRiC subunit CCT2 becomes monomeric and switches its function to autophagy receptor as a second line of ...

A new book, "Protein Homeostasis", ... Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded.

Collectively, the biochemical, structural, genetic and pharmacological studies using a variety of model systems demonstrated a critical role for ZNG1 in regulating cellular zinc homeostasis. “We think ...

Scientists have discovered a family of metallochaperones (ZNG1) that transfer zinc onto proteins and play a significant role maintaining zinc homeostasis and cellular integrity [Weiss et al, Cell ...

A disturbed relationship between chaperone proteins and the protein α-synuclein was linked to cell damage and the development of Lewy bodies, which are common in those diagnosed with Parkinson ...

Despite zinc’s critical role, however, it has not been clear how the metal gets put into proteins that use it or how our cells respond to zinc deficiency, until now. We've ... “Chaperone” Protein ...