The American Academy of Neurology issues new guidelines to help clinicians navigate the use of unproven neurologic therapies lacking FDA approval or strong evidence.

This article investigates pharmaceutical innovation by analysing data on the companies that introduced the ∼1,200 new drugs that have been approved by the US FDA since 1950. Implications of this ...

Methods and Results Endothelium-dependent relaxation to acetylcholine and the calcium ionophore A23187 was reduced in aortic segments from hypercholesterolemic rabbits compared with controls.

Because atherosclerosis develops silently over several decades and begins as early as young adulthood, 1 most investigators foresee a blurring of the distinction between primary and secondary ...

Purpose. The efficacy and safety of phytosterols for the management of dyslipidemia are reviewed. Summary. Phytosterols have been evaluated in over 40 clinical trials. The incorporation of 2 g of ...

Objective Whether statins increase the risk of intracerebral haemorrhage (ICH) in patients with a previous stroke remains uncertain. This study addresses the evidence of statin therapy on ICH and ...

Background. Sepsis was defined as a life-threatening organ dysfunction caused by a deregulated inflammatory response to infection in the Third International Consensus Definitions released in 2016 ...

Background: A study was undertaken in patients with undiagnosed sleep apnoea/hypopnoea syndrome (OSAS) to document the use of prescribed medications, especially those used in cardiovascular diseases, ...

(1) Purpose: This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict the trough concentration (Ctrough) of imatinib (IMA) at steady state in patients and to explore ...