Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like ...

The immune system of vertebrates is a powerful weapon against external pathogens and cancerous cells. T cells play a crucial role in this context. They carry a special receptor called the T-cell ...

During animal development, cells divide and arrange themselves in a coordinated way, eventually forming the embryo. The cells ...

Atomic resolution image of antigen-bound T-cell receptor reveals new understanding of how T-cells are activated.

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

A T cell (pictured) can have many roles in the immune system. (Image courtesy NIAID) Scientists wouldn't normally expect to see a nuclear receptor such as RARα playing this role outside the cell ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

T cells are our immune system’s customized tools for fighting infectious diseases and tumor cells. On their surface, these special white blood cells carry a receptor that recognizes antigens.

G-protein-coupled receptors and their G protein partners are studied by single-molecule imaging in living cells, which reveals hot spots on the cell membrane where receptors and G proteins ...

T cells are able to detect and respond to specific peptide antigens by virtue of the unique T cell receptor (TCR) complexes they express on their cell surface (see image). The TCR of conventional ...

The cLac molecule developed in the lab of Boston College chemist Jianmin Gao latches onto dying cells, while bypassing living cells. When colored with a fluorescent dye in tests, cLac allows ...

Immune system: Image of antigen-bound T-cell receptor at atomic resolution Antigen binding does not trigger any structural changes in T-cell receptors -- Signal transduction probably occurs after ...