Bacterial cell division is an essential process that is not yet targeted by clinically approved antibacterials. However, it is an area of untapped potential, with antibacterial discovery efforts ...

An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers have now found out that this happens through a previously unknown mechanism.

What kind of antibiotic candidates has your membrane-targeted approach opened the door for? In general, larger molecules—things typically above 500 Da—can’t pass through cell membranes ...

Since then, scientists have found dozens of antibiotics, which fight bacteria in a variety of ways. Many antibiotics, including penicillin, work by attacking the cell wall of bacteria.Specifically ...

These channels' natural function is to release molecules from the cell upon hypoosmotic stress (adjustment to low-salt ...

The development and spread of antibiotic resistance represents one of the greatest threats to global health. To overcome these resistances, drugs with novel modes of action are urgently needed.

"These are essentially little pumps that sit in the cell membrane and pump molecules from inside the cell to outside the cell. "Because antibiotics look like the molecules they normally export ...

Antibiotic polymyxin arranges lipopolysaccharide into crystalline structures to solidify the bacterial membrane. Nature Communications . Published online October 21, 2022. doi: 10.1038/s41467-022 ...

Scientists say they have developed a new type of antibiotic to treat a bacteria that is resistant to most current antibiotics and kills a large percentage of people with an invasive infection.

For example, in 2016, Shokat’s lab designed an unusually large inhibitor of the kinase mTOR, which governs cell growth and is often overactive in cancer.