The growing problem of antibiotic resistance has ... of proteins that are localized in the bacterial membrane. But where will the cell-division inhibitors come from? There is increasing evidence ...

Whakaihu Waka researchers have been part of two studies in the battle against drug resistant strains of Mycobacterium ...

Whether bacteria are resistant to antibiotics is often decided at the cell membrane ... cytotoxins and inhibitors, shed light on how this transport process occurs at the membrane, how it is ...

Antibiotic resistance is a growing ... it could be an Achilles heel in the bacterial shield — inhibitors that access BamA would not need to penetrate the cell. Indeed, a proof-of-concept study ...

The primary reason is that the inhibitors are unable to permeate through the bacterial membrane ... cell more effectively," says Dr. Hou. "Then, combining these inhibitors with traditional ...

Some antibiotics, including tetracycline, which is used to treat acne, respiratory tract infections and other conditions, inhibit protein ... of a bacterium's cell membrane, which controls how ...

In addition to the urgent need for new antibiotics ... One focus is on membrane channels in the cell envelope that transport ...

University of Otago – Ōtākou Whakaihu Waka researchers have been part of two groundbreaking studies in the battle against ...

unlike most antibiotics. On one hand, they bind to membrane lipids, destabilizing the bacterial membrane. Additionally, they inhibit two enzymes involved in cell wall and protein synthesis.

To fight this resistance, researchers are creating pharmaceuticals that attack and inhibit the ... cost of creating the antibiotic-degrading enzyme has left the resistant cell population depleted ...

But that process requires that antibiotic molecules cross the bacteria’s cell membrane to reach those ... our tools to develop new assays to find inhibitors for those enzymes.

which could be a potential new target for antibiotics. In the study, the researchers confirmed that this protein, called MurJ, flips a fatty molecule from one side of a bacterial cell membrane to ...