Bacterial cell division is an essential process that is not yet targeted by clinically approved antibacterials. However, it is an area of untapped potential, with antibacterial discovery efforts ...

Whether bacteria are resistant to antibiotics is often decided at the cell membrane. This is where antibiotics can be blocked on their way into the cell interior or catapulted from the inside to ...

In addition to the urgent need for new antibiotics, alternative strategies are required to tackle the problem of antibiotic resistance. Michaela Wenzel, Associate Professor at Chalmers University of ...

What kind of antibiotic candidates has your membrane-targeted approach opened the door for? In general, larger molecules—things typically above 500 Da—can’t pass through cell membranes ...

Our hypothesis is that our compounds, by inducing membrane remodeling, inhibit multiple essential functions simultaneously.” This onslaught of disruption has a multiplicative effect on the bacteria, ...

Beta-Lactam Antibiotics Induce a Lethal Malfunctioning of the Bacterial Cell Wall Synthesis Machinery. Cell , 2014; 159 (6): 1300 DOI: 10.1016/j.cell.2014.11.017 Cite This Page : ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Zoppi, Lois. (2019, August 01). New antibiotics on the horizon as scientists discover a weakness ...

But this antibiotic does not affect the DNA gyrases of humans and thus, again, bacteria die while the host remains unharmed. Many other compounds can kill both bacterial and human cells.

For example, in 2016, Shokat’s lab designed an unusually large inhibitor of the kinase mTOR, which governs cell growth and is often overactive in cancer.