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Researchers identified an unusual genetic mutation in orange domestic cats that has not been found in any other animal, according to a new study.
Typically, mutations that lead to yellow or orange fur in animals (and red hair in humans) occur within genes that control for color. And those genes aren’t carried on the X chromosome.
Male cats, on the other hand, only have one X chromosome, and are therefore much more likely to evenly express that mutation. Whether orange or not, all fur pigmentation genes are X-linked.
In orange cats, the missing segment is located on an intron, or noncoding region, of the ARHGAP36 gene, which is also in neuroendocrine tissues (especially the hypothalamus), adrenal glands, and ...
The secret to this finding is the ARHGAP36 gene, which is most active in the cells that influence skin, fur, and eye pigmentation. In their study, the researchers determined that ginger cats lack ...